Badam gum: a natural polymer in mucoadhesive drug delivery. Design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive tablets
نویسندگان
چکیده
منابع مشابه
Development and optimization of metoprolol succinate gastroretentive drug delivery system.
Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...
متن کاملFormulation and Evaluation of Controlled Release Mucoadhesive Matrix Tablets: Assessment of Myrrh Oleo Gum Resin as a Natural Pharmaceutical Excipient
Mucoadhesive polymer owing to its binding capacity with gastric mucin prolongs the gastric residence time and thereby increased drug bioavailability. In the present study, oral controlled release mucoadhesive matrix tablets have been developed for domperidone as model drug using natural mucoadhesive material myrrh oleo gum resin (MOGR).The tablets were formulated with the natural polymer in dif...
متن کاملDevelopment of Oral Mucoadhesive Tablets of Losartan Potassium using Natural Gum from Manilkara Zapota Seeds
The present investigation reports the isolation of mucilage from Manilkara zapota seeds as per AOAC guideline and evaluating it as mucoadhesive agent. Manilkara zapota (Linn.) P. Royen syn. a small tree belonging to family sapotaceae. Physiochemical characteristics of mucilage, such as swelling index, microbial count, viscosity, hydration capacity, flow property, and pH were studied. The mucila...
متن کاملFormulation Study and Evaluation of Matrix and Three-Layer Matrix Tablets Oral Controlled Drug Delivery System Based on Xanthan Gum and Locust Bean Gum
The present study was carried out to develop oral controlled release matrix tablets and three layer matrix tablets of highly water soluble diltiazem HCl using natural polymers Xanthan gum (XG), locust bean gum (LBG) and a mixture XG: LBG in 1:1 ratio as matrix forming agent, and anionic Sodium Carboxyl Methyl Cellulose as release retardant layer on the matrix core, Di calcium Phosphate (DCP) an...
متن کاملChewing Gum as a Drug Delivery System
In present era, many research and technological advancements are made in the field of oral drug delivery as it is highly accepted amongst patients.. Chewing gum is one of the very popular oral confectionery products. Medicated chewing gums are prepared by using a water insoluble gum base, elastomers, emulsifiers, fillers, waxes, antioxidants, softeners, sweeteners, food colourings, flavoring ag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery
سال: 2014
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2014.908979